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Table 6 Comparison of the efficacy of albendazole alone or with DEC in the current study with data published previously.

From: Tolerability and efficacy of single dose albendazole, diethylcarbamazine citrate (DEC) or co-administration of albendazole with DEC in the clearance of Wuchereria bancroftiin asymptomatic microfilaraemic volunteers in Pondicherry, South India: a hospital-based study

Trials Follow-up time (days post-therapy)
  0 7 30 90 120 180 270 360 15 m*
A) Prevalence (% of cases)
Current study
Alb 400 mg 100.0 100.0 100.0 94.7 - 94.7 84.2 73.7 -
Alb 400 mg + DEC 6 mg/kg bodyweight 100.0 100.0 100.0 100.0 - 94.4 83.3 72.2 -
Previous studies (single dose) Alb 400 mg
Ismail et al., (1998)† - - - - - - - - 91.7
Addiss et al., (1997) - - - - 76.0 - - - -
Beach et al., (1999) - - - - 85.0 - - - -
Dunyo et al., (2000) - - - - - - - 91.9 -
Previous studies (single dose) Alb 400 mg + DEC 6 mg/kg
Ismail et al., (1998)† - - - - - - - - 72.7
B) Changes in parasite density (geometric mean) as compared to pre-therapy level
Current study
Alb 400 mg 100.0 85.9 59.5 34.9 - 25.8 14.5 5.3 -
Alb 400 mg + DEC 6 mg/kg bodyweight 100.0 54.9 39.1 22.0 - 19.0 12.3 4.6 -
Previous studies (single dose) Alb 400 mg
Ismail et al., (1998)† - - - - - - - - 9.8
Addiss et al., (1997) - - - - 63.8 - - - -
Beach et al., (1999) - - - - - - - - -
Dunyo et al., (2000) - - - - - - - 31.7 -
Previous studies (single dose) Alb 400 mg + DEC 6 mg/kg
Ismail et al., (1998)† - - - - - - - - 1.3
  1. -Data not available †albendazole 600 mg *15 months post-therapy Alb = albendazole, DEC = diethylcarbamazine citrate