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Table 2 Presenting symptoms and signs of SAE cases reported to have occurred following ivermectin mass treatment from 1989 to 2001*

From: Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases

Nature of Symptoms Frequency of occurrence† (%) Nature of Signs Frequency of occurrence† (%)
Difficulty or inability to stand or walk 60 (29.0) Altered Mental Status 106 (51.2)
Feverishness 54 (26.1) Fever (documented) 51 (24.6)
Headache 52 (25.1) Incontinence (urinary and/or fecal) 42 (20.3)
General myalgia or arthralgia 51 (24.6) Dysarthria 26 (12.6)
Fatigue/Asthenia 40 (19.3) Subconjunctival hemorrhage 26 (12.6)
Diarrhea 33 (15.9) Rash and/or urticuria 23 (11.1)
Vertigo 31 (15.0) Generalized edema 16 (7.7)
Dyspnea 22 (10.6) Extremity edema 16 (7.7)
Pruritis 20 (9.7) Facial edema 15 (7.3)
Nausea or vomiting 19 (9.1) Hypotension (documented) 13 (6.3)
  1. *cases reported as of August 31, 2002; †total of individual percentages is greater than 100 because most patients presented with multiple symptoms and signs.