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Table 2 Presenting symptoms and signs of SAE cases reported to have occurred following ivermectin mass treatment from 1989 to 2001*

From: Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases

Nature of Symptoms

Frequency of occurrence† (%)

Nature of Signs

Frequency of occurrence† (%)

Difficulty or inability to stand or walk

60 (29.0)

Altered Mental Status

106 (51.2)

Feverishness

54 (26.1)

Fever (documented)

51 (24.6)

Headache

52 (25.1)

Incontinence (urinary and/or fecal)

42 (20.3)

General myalgia or arthralgia

51 (24.6)

Dysarthria

26 (12.6)

Fatigue/Asthenia

40 (19.3)

Subconjunctival hemorrhage

26 (12.6)

Diarrhea

33 (15.9)

Rash and/or urticuria

23 (11.1)

Vertigo

31 (15.0)

Generalized edema

16 (7.7)

Dyspnea

22 (10.6)

Extremity edema

16 (7.7)

Pruritis

20 (9.7)

Facial edema

15 (7.3)

Nausea or vomiting

19 (9.1)

Hypotension (documented)

13 (6.3)

  1. *cases reported as of August 31, 2002; †total of individual percentages is greater than 100 because most patients presented with multiple symptoms and signs.