NATURAL SITUATIONS | ||||
DERMAL RESPONSES | ||||
• | Clinical | |||
Pruritus | ||||
Self-destruction of the skin (mechanical) | ||||
Development of dermal microabscesses | ||||
• | Histopathological | |||
Vascular endothelial activation | ||||
Mast cell increase | ||||
Blood and tissue eosinophilia | ||||
Eosinophil adherence to the surface of the microfilariae | ||||
Macrophage accumulation | ||||
Fragmentation of microfilariae | ||||
Local tissue damage (destruction of collagen, etc.) | ||||
SYSTEMIC EFFECTS | ||||
• | Antigen release | |||
• | Organ dysfunction | |||
• | Cytokine circulation | |||
DRUG INDUCED SITUATIONS (additional activities): | ||||
GENERAL (in addition to those activities in Natural Situations) | ||||
• | Clinical | |||
Migration of microfilariae | ||||
Increased rate of Mf destruction, | ||||
More rapid and severe development of the events | ||||
Progressive movement of the papular response over different parts the body (with low dose DEC) | ||||
• | Histopathological | |||
Macrophage ingestion of excess eosinophil-derived material | ||||
Evidence of immunostimulation |