From: Clinical picture and outcome of Serious Adverse Events in the treatment of Onchocerciasis
Category/Adverse event | Drug and Level of Attribution* | ||||
---|---|---|---|---|---|
Mectizan® | DEC | Metrifonate | Suramin | Amocarzine | |
Death | 1 | 2 | 1 | 4** | 1 |
Syndromes of collapse | |||||
"Therapeutic shock" | 1 | 4 | 4 | 1 | 1 |
Recurrent SSPH | 4 | 4 | 4 | 1 | 4 |
Idiosyncratic | 1 | 1 | 1 | 4 | 1 |
Dermatology/Skin | |||||
Hyper-reactive response | 4 | 4 | 1 | 1 | 1 |
Exfoliative dermatitis | 1 | 1 | 1 | 4 | 1 |
Lymphatic syndromes | 4 | 4 | 4 | 1 | 4 |
Gastrointestinal | |||||
Abdominal colic | 1 | 1 | 4 | 1 | 1 |
GIT† ulceration | 1 | 1 | 1 | 4 | 1 |
Chronic diarrhoea | 1 | 1 | 1 | 4 | 1 |
Pulmonary | |||||
Bronchospasm | 3 | 1 | 3 | 1 | 1 |
Bronchial ulceration | 1 | 1 | 1 | 4 | 1 |
Musculoskeletal | |||||
Acute polyarthritis | 1 | 4 | 4 | 1 | 1 |
Subacute polyarthritis | 1 | 1 | 1 | 4 | 1 |
Hip immobilization | 1 | 1 | 1 | 4 | 1 |
Neurological | |||||
Cerebrotoxicity | 1 | 1 | 1 | 1 | 4 |
Vertigo | 1 | 3 | 1 | 1 | 1 |
Parkinsonian-like state | 1 | 3 | 1 | 1 | 1 |
Proximal muscle weakness | 1 | 1 | 4 | 1 | 1 |
Constitutional symptoms | |||||
Prolonged fever | 1 | 1 | 1 | 4 | 1 |
Prolonged fatigue | 1 | 1 | 1 | 4 | 1 |
Asthenia | 1 | 1 | 1 | 4 | 1 |
Prostration | 1 | 4 | 1 | 4 | 1 |
Hepatic | |||||
Jaundice | 1 | 1 | 1 | 2 | 2 |
Ocular/visual incapacity | 1 | 4 | 1 | 4 | 1 |