Definite Case of Loa Encephalopathy | |
• | Encephalopathy in which brain tissue obtained by autopsy or by needle sampling has microscopic findings consistent with L. loa encephalopathy (vasculopathy with evidence of L. loa microfilariae as a likely etiology), and |
• | Onset of Central Nervous System (CNS) symptoms and signs within 7 days of treatment with ivermectin; illness progressing to coma without remission. |
Probable Case of Loa Encephalopathy | |
• | Encephalopathy (without seizures, usually with fever) in a person previously healthy and has no other underlying cause for encephalopathy, and |
• | Onset of progressive CNS symptoms and signs within 7 days of treatment with ivermectin; illness progressing to coma without remission, and |
• | Peripheral blood L. loa > 10,000 mf/ml pre-treatment or > 1,000 mf/ml within 1 month post-treatment or > 2700 mf/ml within 6 months of treatment; and/or L. loa microfilariae present in cerebrospinal fluid (CSF) within 1 month post-treatment. |
Possible Case of Loa Encephalopathy | |
• | Encephalopathy (without seizures, usually with fever) in a person previously healthy and has no other underlying cause for encepahalopathy, and |
• | Onset of progressive CNS symptoms and signs within 7 days of treatment with ivermectin; illness progressing to coma without remission, and |
• | Semi-quantitative or non-quantitative positive (i.e. +, ++, +++) L. loa microfilariae in peripheral blood within 1 month post-treatment. |
Encephalopathy of other known etiology | |
• | Encephalopathy with sufficient clinical information to determine an etiology other than L. loa (e.g. cerebral malaria) |
Encephalopathy of unknown etiology | |
• | Encephalopathy (without seizures, usually with fever) in a person previously healthy and has no other underlying cause for encephalopathy, and |
• | Onset of progressive CNS symptoms and signs within 7 days of treatment with ivermectin, and |
• | Clinical and/or laboratory findings are inadequate to determine probable etiology. |