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Table 4 Frequency of clinical signs and symptoms of PLERM cases reported to have occurred in onchocerciasis mass treatment programs from 1989 to 2001*

From: Loa loa encephalopathy temporally related to ivermectin administration reported from onchocerciasis mass treatment programs from 1989 to 2001: implications for the future

Clinical sign or symptom

Frequency of occurrence (%)

Altered mental status

65 (100)

   - confusion, obtundation or lethargy

   - 31 (47.7)

   - stupor

   - 13 (20.0)

   - coma

   - 21 (32.3)

Incontinence (urinary & fecal)

28 (43.1)

Difficulty standing up or walking

25 (38.5)

Dysarthria or aphasia

21 (32.3)

Fever (documented)

19 (29.2)

Diarrhea

16 (24.6)

Headache

15 (23.1)

Low back pain

10 (15.4)

Feverishness or chills

10 (15.4)

  1. *cases reported as of August 31, 2002.