Skip to main content

Table 3 Estimated risk of death or chronic disability per 1 million population resulting from L. loa encephalopathy following mass treatment with Mectizan®, under conditions of: 1) no mass treatment; 2) mass treatment with no risk reduction strategy; and 3) mass treatment using REA, RAPLOA-40, RAPLOA-20, or combined REA/RAPLOA-40 to reduce risk of L. loa encephalopathy. Four scenarios are considered based on high and low prevalence of loiasis and onchocerciasis, respectively (defined in the Appendix - see additional file 1).

From: A Framework for Decision-Making for Mass Distribution of Mectizan® in Areas Endemic for Loa loa

Loiasis Prevalence

High

High

Low

Low

Onchocerciasis Prevalence

High

Low

High

Low

No Mectizan® treatment

0

0

0

0

Mectizan® treatment

    

   No risk-reduction strategy

85.1

85.1

26.0

26.0

   REA

5.1

3.4

0.5

0.3

   RAPLOA-40

12.9

12.9

2.0

2.0

   RAPLOA-20

5.6

5.6

0.6

0.6

   REA/RAPLOA-40

12.4

11.0

2.0

1.9