Figure 2

Indomethacin or dexamethasone pre-treatment reduces efficacy of DEC in BALB/c mice infected with B. malayi microfilariae. Indomethacin (10 mg/kg), dexamethasone (3 mg/kg) or vehicle was administered 30 minutes before oral dosing with DEC (100 mg/kg). Symbols are means of three mice for the DEC plus dexamethasone group (triangles), seven mice for the DEC plus indomethacin group (white circles) and four mice for the DEC-only group (black circles). Significantly different results from the DEC-only group are denoted by * (P < 0.017), ** (P = 0.001) or *** (P = 0.000).