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Table 2 Nodule counts (including all removed nodules at 24 mpt), diameter (means ± standard deviations) and median age scores of female worms before and 24 months after the start of treatment in cattle, following 7 monthly treatments with ivermectin 500 μg/kg subcutaneously, doramectin 500 μg/kg subcutaneously or no treatment. Nodule numbers were adjusted for nodules removed for assay. (the number of animals in each group, n = 3 except ‡ n = 2; number of nodules per group, n = 6 except * where n = 4).

From: Repeated high doses of avermectins cause prolonged sterilisation, but do not kill, Onchocerca ochengiadult worms in African cattle

Timepoint 0 mpt 24 mpt
  count1 Diameter2 (mm) ♀age score3 count Diameter (mm) ♀age score
Control 75 ± 26 5.9 ± 0.6 1.5 61 ± 25 ‡ 6.7 ± 0.7* 2*
Ivermectin 73 ± 25 7.4 ± 1.2 1 72 ± 19 6.5 ± 0.4 3
Doramectin 73 ± 35 6.9 ± 1.1 2 66 ± 36 6.9 ± 0.9 3
  1. 1 Two-way ANOVA: effect of interaction of treatment and mpt p = 0.630; effect of treatment p = 0.891; effect of mpt p = 0.510
  2. 2 Two-way ANOVA: effect of interaction of treatment and mpt p = 0.270;effect of treatment p = 0.403; effect of mpt p = 0.996
  3. 3 Not tested statistically