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Table 2 Nodule counts (including all removed nodules at 24 mpt), diameter (means ± standard deviations) and median age scores of female worms before and 24 months after the start of treatment in cattle, following 7 monthly treatments with ivermectin 500 μg/kg subcutaneously, doramectin 500 μg/kg subcutaneously or no treatment. Nodule numbers were adjusted for nodules removed for assay. (the number of animals in each group, n = 3 except ‡ n = 2; number of nodules per group, n = 6 except * where n = 4).

From: Repeated high doses of avermectins cause prolonged sterilisation, but do not kill, Onchocerca ochengiadult worms in African cattle

Timepoint

0 mpt

24 mpt

 

count1

Diameter2 (mm)

♀age score3

count

Diameter (mm)

♀age score

Control

75 ± 26

5.9 ± 0.6

1.5

61 ± 25 ‡

6.7 ± 0.7*

2*

Ivermectin

73 ± 25

7.4 ± 1.2

1

72 ± 19

6.5 ± 0.4

3

Doramectin

73 ± 35

6.9 ± 1.1

2

66 ± 36

6.9 ± 0.9

3

  1. 1 Two-way ANOVA: effect of interaction of treatment and mpt p = 0.630; effect of treatment p = 0.891; effect of mpt p = 0.510
  2. 2 Two-way ANOVA: effect of interaction of treatment and mpt p = 0.270;effect of treatment p = 0.403; effect of mpt p = 0.996
  3. 3 Not tested statistically