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Table 1 Sensitivities and specificities of WB rapid and panLF rapid tests evaluated at five institutions.

From: Multicentre evaluations of two new rapid IgG4 tests (WB rapid and panLF rapid) for detection of lymphatic filariasis

 

WB rapid

panLF rapid

 

Wb

Bm/Bt

*Other infec-tions

Nor-mals

Sens & Spec

Wb

Bm/Bt

*Other infections

Normals

Sens & Spec

UI

43 (43)

-

0 (13)

-

100% sens

100% spec

24 (24)

35 (38)

-

-

Overall

sens: 95%

Wb: 100% sens

Bm: 92% sens

UM

30 (30)

-

0 (58)

0 (10)

100% sens

100% spec

30 (30)

29 (29)

0 (60)

0 (10)

100% sens (Bm & Wb)

100% spec

AMU

102 (104)

-

-

0 (48)

98% sens

100% spec

99 (104)

-

-

0 (48)

95% sens (Wb)

100% spec

USM

47 (50)

-

1 (65)

0 (50)

94% sens

99% spec

47 (50)

109 (111)

1 (65)

0 (50)

Overall sens: 97%

Wb: 94% sens

Bm: 98% sens

99% spec

ILS

17 (18)

-

-

-

94% sens

17 (18)

-

-

-

94% sens (Wb)

  1. Note: Numbers indicate number of samples that were positive, and numbers in parenthesis were the number of samples tested.
  2. UI : University of Indonesia, Indonesia
  3. UM : University of Malaya, Malaysia
  4. AMU : Aichii Medical University, Japan
  5. USM : Universiti Sains Malaysia, Malaysia
  6. ILS : Institute of Life Sciences, India
  7. sens : sensitivity; spec : specificity
  8. Wb: Wuchereria bancrofti ; Bm: Brugia malayi ; Bt: Brugia timori
  9. Filarial samples tested in Indonesia, Malaysia and India came from mf+ individuals; while those tested in Japan also came from individuals who are mf-, CFA+ (>512 units).
  10. *Other infections: ascariasis, trichuriasis, hookworm, strongyloidiasis, toxocariasis, toxoplasmosis, typhoid, cysticercosis, schistosomiasis, malaria, dengue, amoebiasis
  11. WB rapid: sensitivity : 97.6% (239/245); specificity : 99.6% (243/244)
  12. panLF rapid: overall sensitivity : 96.5% (390/404); sensitivity for Wb detection: 96.0% (217/226); sensitivity for Bm/Bt detection: 97.2% (173/178); specificity: 99.6% (232/233)