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  1. Research

    Onchocerca parasites and Wolbachia endosymbionts: evaluation of a spectrum of antibiotic types for activity against Onchocerca gutturosa in vitro

    The filarial parasites of major importance in humans contain the symbiotic bacterium Wolbachia and recent studies have shown that targeting of these bacteria with antibiotics results in a reduction in worm viabil...

    Simon Townson, Senyo Tagboto, Helen F McGarry, Gillian L Egerton and Mark J Taylor

    Filaria Journal 2006 5:4

    Published on: 24 March 2006

  2. Research

    PCR and dissection as tools to monitor filarial infection of Aedes polynesiensismosquitoes in French Polynesia

    Entomological methods may provide important tools for monitoring the transmission of filariasis in French Polynesia. In order to standardize our PCR method and refine our protocol to assess filarial infection ...

    Catherine Plichart, Yves Sechan, Neil Davies and Anne-Marie Legrand

    Filaria Journal 2006 5:2

    Published on: 24 February 2006

    The Erratum to this article has been published in Filaria Journal 2007 6:5

  3. Research

    Assessment of microfilarial loads in the skin of onchocerciasis patients after treatment with different regimens of doxycycline plus ivermectin

    Infection with the filarial nematode Onchocerca volvulus can lead to severe dermatitis, visual impairment, and ultimately blindness. Since the currently used drug, ivermectin does not have macrofilaricidal or str...

    Alexander Yaw Debrah, Sabine Mand, Yeboah Marfo-Debrekyei, John Larbi, Ohene Adjei and Achim Hoerauf

    Filaria Journal 2006 5:1

    Published on: 5 February 2006

  4. Research

    A flow cytometry based method for studying embryogenesis and immune reactivity to embryogenic stages in filarial parasites

    In the absence of intermediate animal hosts, the process of embryogenesis leading to fecundity of adult female filarial worms is very critical for persistence of these obligate parasites in human communities. ...

    Bikash Ranjan Sahu, Alok Das Mohapatra, Arindam Majumder, Pradip K Das and Balachandran Ravindran

    Filaria Journal 2005 4:11

    Published on: 7 November 2005

  5. Review

    The chromosomes of the Filariae

    An understanding of the nature of the chromosomes of the filariae is expected to greatly assist the future interpretation of genome data. Filarial development is not eutelic, and there does not seem to be a fi...

    Rory Post

    Filaria Journal 2005 4:10

    Published on: 2 November 2005

  6. Research

    Studies on Acanthocheilonema viteae cystatin: Genomic organization, promoter studies and expression in Caenorhabditis elegans

    Cystatins are reversible, tightly binding inhibitors of cysteine proteases. Filarial cystatins have been ascribed immunomodulatory properties and have been implicated in protective immunity. To continue explor...

    Smitha Pillai, Bernd H Kalinna, Eva Liebau, Susanne Hartmann, Franz Theuring and Richard Lucius

    Filaria Journal 2005 4:9

    Published on: 9 August 2005

  7. Research

    Repeated high doses of avermectins cause prolonged sterilisation, but do not kill, Onchocerca ochengiadult worms in African cattle

    Ivermectin (Mectizan™, Merck and CO. Inc.) is being widely used in the control of human onchocerciasis (Onchoverca volvulus) because of its potent effect on microfilariae. Human studies have suggested that, at th...

    Barend M deC Bronsvoort, Alfons Renz, Virginia Tchakouté, Vincent N Tanya, David Ekale and Alexander J Trees

    Filaria Journal 2005 4:8

    Published on: 8 August 2005

  8. Short paper

    Mass ivermectin treatment for Onchocerciasis: Lack of evidence for collateral impact on transmission of Wuchereria bancroftiin areas of co-endemicity

    There has long been interest in determining if mass ivermectin administration for onchocerciasis has 'unknowingly' interrupted lymphatic filariasis (LF) transmission where the endemicity of the two diseases' o...

    FO Richards Jr, A Eigege, D Pam, A Kal, A Lenhart, JOA Oneyka, MY Jinadu and ES Miri

    Filaria Journal 2005 4:6

    Published on: 15 July 2005

  9. Research

    Impact of two rounds of mass drug administration using diethylcarbamazine combined with albendazole on the prevalence of Brugia timoriand of intestinal helminths on Alor Island, Indonesia

    Annual mass drug administration (MDA) using diethylcarbamizine (DEC, 6 mg/kg) combined with albendazole (alb, 400 mg) is recommended by the Global Programme to Eliminate Lymphatic Filariasis (GPELF). This stra...

    Tim Oqueka, Taniawati Supali, Is Suhariah Ismid, Purnomo, Paul Rückert, Mark Bradley and Peter Fischer

    Filaria Journal 2005 4:5

    Published on: 13 July 2005

  10. Short paper

    The subcutaneous movements of filarial infective larvae are impaired in vaccinated hosts in comparison to primary infected hosts

    Our aim in this study was to observe the movements of filarial infective larvae following inoculation into the mammalian host and to assess the effect of vaccination on larval migration, in situ. Here we present ...

    Simon A Babayan, Tarik Attout, Phat N Vuong, Laetitia Le Goff, Jean-Charles Gantier and Odile Bain

    Filaria Journal 2005 4:3

    Published on: 25 May 2005

  11. Research

    Combined Utilisation of Rapid Assessment Procedures for Loiasis (RAPLOA) and Onchocerciasis (REA) in Rain forest Villages of Cameroon

    Individuals with high microfilarial loads of Loa loa are at increased risk of neurologic serious adverse (SAE) events following ivermectin treatment against onchocerciasis. RAPLOA (Rapid Assessment Procedure for ...

    Samuel Wanji, Nicholas Tendongfor, Mathias Esum, Siker SJ Yundze, Mark J Taylor and Peter Enyong

    Filaria Journal 2005 4:2

    Published on: 7 April 2005

  12. Research

    Frequent detection of worm movements in onchocercal nodules by ultrasonography

    Ultrasonography (USG) is known to be a suitable tool for diagnosis in lymphatic filariasis as the adult filarial nematode Wuchereria bancrofti in scrotal lymphatic vessels of infected men can be detected by the c...

    Sabine Mand, Yeboah Marfo-Debrekyei, Alex Debrah, Marcelle Buettner, Linda Batsa, Kenneth Pfarr, Ohene Adjei and Achim Hoerauf

    Filaria Journal 2005 4:1

    Published on: 23 March 2005

  13. Research

    Homologs of the Brugia malayi diagnostic antigen BmR1 are present in other filarial parasites but induce different humoral immune responses

    The recombinant antigen BmR1 has been extensively employed in both ELISA and immunochromatographic rapid dipstick (Brugia Rapid) formats for the specific and sensitive detection of IgG4 antibodies against the lym...

    Rahmah Noordin, Ros Azeana Abdul Aziz and Balachandran Ravindran

    Filaria Journal 2004 3:10

    Published on: 31 December 2004

  14. Research

    Recombinant antigen-based antibody assays for the diagnosis and surveillance of lymphatic filariasis – a multicenter trial

    The development of antifilarial antibody responses is a characteristic feature of infection with filarial parasites. It should be possible to exploit this fact to develop tools to monitor the progress of the g...

    Patrick J Lammie, Gary Weil, Rahmah Noordin, Perumal Kaliraj, Cathy Steel, David Goodman, Vijaya B Lakshmikanthan and Eric Ottesen

    Filaria Journal 2004 3:9

    Published on: 3 September 2004

  15. Research

    Comparison of IgG4 assays using whole parasite extract and BmR1 recombinant antigen in determining antibody prevalence in brugian filariasis

    Brugia malayi is endemic in several Asian countries with the highest prevalence in Indonesia. Determination of prevalence of lymphatic filariasis by serology has been performed by various investigators using diff...

    Rahmah Noordin, Sitti Wahyuni, Andarias Mangali, Lim Boon Huat, Maria Yazdanbakhsh and Erliyani Sartono

    Filaria Journal 2004 3:8

    Published on: 12 August 2004

  16. Research

    Mapping the distribution of Loa loain Cameroon in support of the African Programme for Onchocerciasis Control

    Loa loa has recently emerged as a filarial worm of significant public health importance as a consequence of its impact on the African Programme for Onchocerciasis Control (APOC). Severe, sometimes fatal, encephal...

    Madeleine C Thomson, Valérie Obsomer, Joseph Kamgno, Jacques Gardon, Samuel Wanji, Innocent Takougang, Peter Enyong, Jan H Remme, David H Molyneux and Michel Boussinesq

    Filaria Journal 2004 3:7

    Published on: 6 August 2004

  17. Research

    Spatial clustering of filarial transmission before and after a Mass Drug Administration in a setting of low infection prevalence

    In the global program for the elimination of lymphatic filariasis (LF) longitudinal assessment of the prevalence of microfilaremia and antigenemia is recommended to monitor the effect of mass treatment on tran...

    Charles H Washington, Jeanne Radday, Thomas G Streit, Heather A Boyd, Michael J Beach, David G Addiss, Rodrigue Lovince, Maribeth C Lovegrove, Jack G Lafontant, Patrick J Lammie and Allen W Hightower

    Filaria Journal 2004 3:3

    Published on: 5 May 2004

  18. Research

    Antibody responses to Brugia malayiantigens induced by DNA vaccination

    DNA vaccination is a convenient means of immunizing animals with recombinant parasite antigens. DNA delivery methods are believed to affect the qualitative nature of immune responses to DNA vaccines in ways th...

    Ben-Wen Li, Amy Rush, Shaorong R Zhang, Kurt C Curtis and Gary J Weil

    Filaria Journal 2004 3:1

    Published on: 22 January 2004

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