Lymphatic Filariasis (Elephantiasis) Elimination: A public health success and development opportunity
© Molyneux; licensee BioMed Central Ltd. 2003
Received: 19 August 2003
Accepted: 09 September 2003
Published: 09 September 2003
The Global Programme to Eliminate Lymphatic Filariasis, launched following World Health Assembly Resolution 50.29 (WHA 50.29), has been facilitated in its progress by new research findings, drug donations, the availability of diagnostic tools, disability management strategies to help those already suffering and the development of partnerships. The strategy recommended by the World Health Organization of annual treatment with a two-drug combination has proved safe.
Using different approaches in several countries the elimination of lymphatic filariasis (LF) has been demonstrated to be feasible during earlier decades. These successes have been largely overlooked. However, the programme progress since 2000 has been remarkable – upscaling rapidly from 2 million treatments in 2000 to approximately 60 million in 2002. Around 34 countries had active programmes at the end of 2002. It is anticipated that there will be further expansion – but this will be dependent on additional resources becoming available. The programme also provides significant opportunities for other disease control programmes to deliver public health benefits on a large scale. Few public health programmes have upscaled so rapidly and so cost-effectively (<$0.03/treatment in some Asian settings) – one country treating 9–10 million people in a day (Sri Lanka). The LF programme is arguably the most effective pro-poor public health programme currently operating which is based on country commitment and partnerships supported by a global programme and alliance. Tables are provided to summarize programme characteristics, the benefits of LF elimination, opportunities for integration with other programmes and relevance to the Millennium Development Goals.
Lymphatic filariasis elimination is an "easy-to-do" inexpensive health intervention that provides considerable "beyond filariasis" benefits, exemplifies partnership and is easily evaluated. The success in global health action documented in this paper requires and deserves further support to bring to fruition elimination of lymphatic filariasis as a public health problem and health benefits to poor people. A future free of lymphatic filariasis will reduce poverty and bring better health to poor people, prevent disability, strengthen health systems and build partnerships.
• Caused by thread-like parasitic worms (Wuchereria bancrofti, Brugia malayi and Brugia timori) that damage the human lymphatic system – transmitted by mosquitoes (see additional file 1)
• One of the most disabling and disfiguring of diseases
• 80+ endemic countries (Figure 1)
• 1+ billion people are at risk of infection
• 120 million people are infected. Of these...
• 43 million people have swelling of the limbs and breasts (known as lymphoedema) and genitals (known as hydrocoele), and their more chronic state – known as elephantiasis – in which the skin becomes enormously thickened, and is rough, hard, and fissured
• It is a disease of poverty – affecting the "poorest of the poor" – preventing those afflicted from living a normal working and social life (See additional file 2)
• Children acquire the disease early and are blighted for life
Intensive research over the last decade has shown the efficacy of new drug combinations , created simple diagnostic tools  (See additional file 3), improved knowledge of pathology [4, 5] (See additional file 4) and demonstrated that those with existing disability could have symptoms of lymphoedema and elephantiasis alleviated by community home-based care .
Lymphatic Filariasis as a unique and successful programme
• Two drugs (largely donated or inexpensive) once per year for time limited duration
• DEC + albendazole in areas where onchocerciasis is not endemic
• Albendazole + Mectizan® where onchocerciasis is co-endemic with lymphatic filariasis
• Two major pharmaceutical companies involved
• A global disease (80 endemic countries; 1+ billion at risk) but regionalised programmatically
• Many synergistic/integration opportunities in the programme (See Table 4)
• Major successes already demonstrated
• Disability alleviation and prevention component to increase coverage and compliance via household and community self help
• Mass drug distribution – an overtly pro-poor intervention
• Intervention provides entry point to both rural and urban health settings
• Different drug distribution systems dependent on country decisions
• Separation of programmatic and GAELF responsibilities
• A free non-restrictive alliance with diverse partners
• Strong involvement of academic institutions and research funders
• Wide use of IT for dissemination and communication
The development of a new strategy – time limited (at least 5 years) – annual co-administration of two drugs and the creation of GPELF and the Global Alliance for the Elimination of Lymphatic Filariasis (GAELF) builds on successful lymphatic filariasis elimination programmes in several countries [7–9]. These countries in different endemic areas and epidemiological settings have convincingly demonstrated that transmission could be stopped permanently. China, Japan, Korea, Thailand and the Solomon Islands using different strategies have eliminated transmission; Sri Lanka has eliminated Brugian filariasis and smaller foci in Brazil, Malaysia, Costa Rica, Suriname and Trinidad and Tobago have been eliminated .
The establishment of a diverse partnership in 2000 to form GAELF and the endorsement of the WHO strategic plan created a momentum that has resulted in 34 countries establishing active programmes. The programme has expanded rapidly with the number of people treated annually rising from 2.9 million in 12 countries in 2000 to 28.89 million in 2001 and an estimated 60 million in 34 countries in 2002 . This upscaling occurred as the safety and tolerability of the drug combinations was confirmed on an increasingly large scale, as the extent of the disease and its consequent disabling effects on poor people were recognised, and as the magnitude of the latent burden in children was appreciated at the same time that new diagnostic tests revealed that children acquire infection at an early age  (One study from Haiti found that by the age four more than 25% of children were already infected ). These findings were recognised by many endemic countries who considered that LF was a priority as a disease that could be eliminated as public health problem, thus improving productivity and well-being of affected communities through reducing costs to individuals, communities and under-resourced health systems and enhancing earning capacity through increased productivity in various sectors.
The benefits of Lymphatic Filariasis elimination
• Lymphatic Filariasis transmission stopped
• Intestinal helminth burden reduced
• Anaemia caused by hookworm alleviated
• Disability alleviated and skin diseases controlled
• Nutritional status improved
• Health systems strengthened
• Improved surveillance, monitoring and evaluation
• Enhanced drug distribution system
• Social mobilisation approaches improved
• Linkage of LF to other disease interventions
• Increased human resource capacity in health
• Strengthened knowledge of disease distribution
• Reduced costs to poor families who seek inappropriate treatment
• Reduced costs of surgery at district level
• Increased school attendance
• A bridge to other public-private partnerships
Opportunities for integration and synergy with other programmes
• Vector control via bednets with malaria control
• Vector control of dengue vectors
• Intestinal helminths/Schistosomiasis programmes via schools
• Addition of DEC to iodinated/fluoridated salt (with the possibility of fortification with other micronutrients)
• Onchocerciasis control linkage in Africa where onchocerciasis/LF are co-endemic
• Linkage to guinea-worm programme for surveillance and drug distribution
• Use of National Immunisation Days for annual treatment
• Evaluation and rapid appraisal systems can link to other diseases e.g. anaemia and malaria, vector status, Loa loa, schistosomiasis, onchocerciasis
• Linkages to Vitamin A and Zithromax (Trachoma) distribution programmes
Lymphatic Filariasis elimination and the Millennium Development Goals
• Eliminate extreme poverty and hunger
• LF is a disease of poor people in poor countries, particularly in individuals earning below $1/day. LF elimination reduces health care costs and increases productivity
• Reduces prevalence of underweight children by improving nutritional status, micronutrient uptake enhanced through albendazole and by improvement of agricultural productivity and improving household/community food security
• Achieve universal primary education
• LF elimination will increase capacity of poor families to access education through increased income, reduced caring for afflicted parents, increased school attendance and performance via drug treatment impact on intestinal helminths
• Schools can act as an entry point for drug distribution, increasing both coverage and parental awareness of the benefits
• Promote gender equity and empowerment
• Women play a role as drug distributors enhancing respect and empowerment
• Women's marital prospects enhanced as LF control reduces stigma of disease
Goal 4 and Goal 5
• Reduce child mortality and reduce maternal mortality
• Women's health status improves as albendazole alleviates hookworm anaemia
• Anaemia → better birth outcomes → reduced prevalence of low birth weight babies hence reduced maternal and infant mortality
• Combat HIV/AIDS/malaria and other diseases
• LF and malaria control interlinked by bednets, alleviation of anaemia by albendazole; drug distribution can enhance bednet coverage and re-impregnation rates
• Albendazole impacts on child and maternal mortality via alleviation of anaemia burden
Goal 7 and Goal 8
• Ensure environmental sustainability
• Develop a Global partnership for Development
• GAELF and GPELF are an effective diverse global partnership committed to elimination of a disease of poverty by 2020.
• Elimination has been achieved in several countries bringing development benefits to poor communities
Lymphatic filariasis elimination is an "easy-to-do" inexpensive health intervention that provides considerable "beyond filariasis" benefits (Tables 4 and 5), exemplifies partnership and is easily evaluated. The success in global health action documented here requires and deserves further support to bring to fruition elimination of lymphatic filariasis as a public health problem and health benefits to poor people. A future free of lymphatic filariasis will reduce poverty and bring better health to poor people, prevent disability, strengthen health systems and build partnerships.
If the international health community cannot deliver two safe efficacious drugs annually – which are largely free – which in addition to stopping transmission of lymphatic filariasis also bring profound additional health benefits, it is difficult to expect more complex interventions to succeed in controlling other infectious diseases.
The Global Alliance for the Elimination of Lymphatic Filariasis has the skills, commitment and partnerships to succeed, thereby preventing the next generation of children being infected and subsequently afflicted by this most stigmatising of diseases. There is, however, a need for significant new resources to be committed to achieve this goal.
The author wishes to express his appreciation to the following organizations for their financial support: the UK Department for International Development http://www.dfid.gov.uk/, GlaxoSmithKline http://www.gsk.com/filariasis/ and the Bill and Melinda Gates Foundation http://www.gatesfoundation.org/; and to the following colleagues for their comments and suggestions on this manuscript: Dr Francecso Rio (Lymphatic Filariasis Elimination, WHO), Dr Brian Bagnall (Global Community Partnerships, GlaxoSmithKline), Dr David Addiss and Dr Pat Lammie (Division of Parasitic Diseases, Centers for Disease Control and Prevention), Dr Bernhard Liese (World Bank) and Mr Michael Brown and Mrs Joan Fahy (Lymphatic Filariasis Support Centre, Liverpool School of Tropical Medicine).
- Recommendations of the International Task Force for Disease Eradication. MMWR Recomm Rep. 1993, 42: 1-38.Google Scholar
- Ismail MM, Jayakody RL, Weil GJ, Nirmalan N, Jayasinghe KS, Abeyewickrema W, Rezvi Sheriff MH, Rajaratnam HN, Amarasekera N, de Silva DC, Michalski ML, Dissanaike AS: Efficacy of single dose combinations of albendazole, ivermectin and diethylcarbamazine for the treatment of bancroftian filariasis. Trans R Soc Trop Med Hyg. 1998, 92: 94-97.View ArticlePubMedGoogle Scholar
- Weil GJ, Lammie PJ, Weiss N: The ICT Filariasis Test: A Rapid-format Antigen Test for Diagnosis of Bancroftian Filariasis. Parasitol Today. 1997, 13: 401-404.View ArticlePubMedGoogle Scholar
- Amaral F, Dreyer G, Figueredo-Silva J, Noroes J, Cavalcanti A, Samico SC, Santos A, Coutinho A: Live adult worms detected by ultrasonography in human Bancroftian filariasis. Am J Trop Med Hyg. 1994, 50: 753-757.PubMedGoogle Scholar
- Mand S, Marfo-Debrekyei Y, Dittrich M, Fischer K, Adjei O, Hoerauf A: Animated documentation of the filaria dance sign (FDS) in bancroftian filariasis. Filaria J. 2003, 2: 3-PubMed CentralView ArticlePubMedGoogle Scholar
- Dreyer G, Addiss D, Dreyer P, Norões J: Basic Lymphoedema Management. Treatment and prevention of problems associated with lymphatic filariasis. 2002, New Hampshire, Hollis, 112-1Google Scholar
- Molyneux DH, Neira M, Liese B, Heymann D: Lymphatic filariasis: setting the scene for elimination. Trans R Soc Trop Med Hyg. 2000, 94: 589-591.View ArticlePubMedGoogle Scholar
- Ottesen EA, Duke BO, Karam M, Behbehani K: Strategies and tools for the control/elimination of lymphatic filariasis. Bull World Health Organ. 1997, 75: 491-503.PubMed CentralPubMedGoogle Scholar
- Molyneux DH, Zagaria N: Lymphatic filariasis elimination: progress in global programme development. Ann Trop Med Parasitol. 2002, 96 Suppl 2: S15-40.View ArticlePubMedGoogle Scholar
- Brown MJ, Njongmeta LH, Addiss D, Ngwira B, Fiack C, Ottesen EA, Bassanez M, Molyneux DH: Review of historical data of lymphatic filariasis control programmes - Evidence that lymphatic filariasis can be eliminated as a public health problem. Filaria J. 2003, In press:Google Scholar
- Lymphatic filariasis. Wkly Epidemiol Rec. 2003, 78: 171-179.Google Scholar
- Witt C, Ottesen EA: Lymphatic filariasis: an infection of childhood. Trop Med Int Health. 2001, 6: 582-606.View ArticlePubMedGoogle Scholar
- Lammie PJ, Reiss MD, Dimock KA, Streit TG, Roberts JM, Eberhard ML: Longitudinal analysis of the development of filarial infection and antifilarial immunity in a cohort of Haitian children. Am J Trop Med Hyg. 1998, 59: 217-221.PubMedGoogle Scholar
- Bockarie MJ, Tisch DJ, Kastens W, Alexander ND, Dimber Z, Bockarie F, Ibam E, Alpers MP, Kazura JW: Mass treatment to eliminate filariasis in Papua New Guinea. N Engl J Med. 2002, 347: 1841-1848.View ArticlePubMedGoogle Scholar
- Addiss DG: Mass treatment of filariasis in New Guinea. N Engl J Med. 2003, 348: 1179-81; author reply 1179-81.View ArticlePubMedGoogle Scholar
- Galvez Tan JZ: The Elimination of Lymphatic Filariasis: A Strategy for Poverty Alleviation and Sustainable Development - Perspectives from the Philippines. Filaria J. 2003, 2: 12-PubMed CentralView ArticlePubMedGoogle Scholar
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